ive of

hydroxy-4-etoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide was synthesized in an expedient man-ner through specification and transamidation respec-tively, of ester-functionalized pyrazoles. This synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kinases. Computational design and study of novel 3-(4-chlorophenyl)-5-(3hydroxy-4-etoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide is reported. This computational predic-tion analysis will improve the understanding of candi-date drugs and help in identifying its properties and effects on the human body. Simulation analysis of can-didate drugs is necessary for providing clues about regulatory mechanisms, biochemical pathways and broader drug functions