Add to ORKGAbstract: Sepsis is characterized by a systemic inflammatory response. Systemic physiologic changes can occur and lead to cellular damage and organ failure. The nuclear receptor, peroxisome proliferator-activated receptor- (PPAR), is involved in the regulation of the inflammatory response and is altered in sepsis. Thiazolidinediones (TZDs), and the cyclopentenone prostaglandin, 15d-PGJ2, are specific PPAR agonists. Preclinical experimental in vitro and in vivo studies have demonstrated that pharmacological activation of PPAR provides potent anti-inflammatory effects. These agents may have effects at altering the inflammatory response in clinical sepsis
BACKGROUND & AIMS: Although the role of inflammation to combat infection is known, the contribution ...
Abstract Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill chil...
Introduction: Immune paralysis with massive T-cell apoptosis is a central pathogenic event during se...
Major trauma results in a strong inflammatory response in injured tissue. This posttraumatic hyperin...
INTRODUCTION: PPARβ/δ agonists are known to modulate the systemic inflammatory response after sepsis...
Rationale: Peroxisome proliferator activated receptor (PPAR)-beta/delta is a transcription factor th...
Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the first step...
Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response ...
Abstract—Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription fact...
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins tha...
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins tha...
Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestra...
The peroxisome proliferator-activated receptor-α (PPAR- α) is a member of the nuclear rece...
Peroxisome proliferator-activated receptors (PPARs) are shown to modulate the pathological status of...
Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of ...
BACKGROUND & AIMS: Although the role of inflammation to combat infection is known, the contribution ...
Abstract Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill chil...
Introduction: Immune paralysis with massive T-cell apoptosis is a central pathogenic event during se...
Major trauma results in a strong inflammatory response in injured tissue. This posttraumatic hyperin...
INTRODUCTION: PPARβ/δ agonists are known to modulate the systemic inflammatory response after sepsis...
Rationale: Peroxisome proliferator activated receptor (PPAR)-beta/delta is a transcription factor th...
Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the first step...
Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response ...
Abstract—Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription fact...
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins tha...
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins tha...
Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestra...
The peroxisome proliferator-activated receptor-α (PPAR- α) is a member of the nuclear rece...
Peroxisome proliferator-activated receptors (PPARs) are shown to modulate the pathological status of...
Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of ...
BACKGROUND & AIMS: Although the role of inflammation to combat infection is known, the contribution ...
Abstract Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill chil...
Introduction: Immune paralysis with massive T-cell apoptosis is a central pathogenic event during se...