RESEARCH ARTICLE Competitive amplification o e

which cells acquire specific growth advantages through a stepwise accumulation of mitotically heritable changes targeted therapy. New therapies targeting specific molecular changes in Kristensen et al. BMC Cancer 2012, 12:548 http://www.biomedcentral.com/1471-2407/12/548[2,3]. EGFR and KRAS are part of the same signalingWilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark Full list of author information is available at the end of the articlein the function of cancer related genes, which may be oncogenes, tumor suppressor genes, and DNA repair genes. Most cancers are extremely complex at the mo-lecular level, and two patients suffering from the same cancer disease may have acquired very different cellular alterations. Consequently, there is a huge potential in tumors of individual patients have started to introduce a paradigm shift for cancer treatment. Most cancer patients are now tested for one or more molecular biomarkers i