Restimulating Interest in Cytomegalovirus as a Cofactor for HIV Infection

Cytomegalovirus (CMV) is a complex virus that continues to contribute to mor-bidity in a range of patients. These include solid organ and stem cell trans-plant recipients, in whom the virus is as-sociated with both direct effects, such as CMV hepatitis [1] and gastrointestinal disease, and indirect effects, including acute rejection, reduced long-term graft function, accelerated posttransplantation vascular disease, and, in some cases, death [2]. In addition, CMV remains an important cause of congenital disease, leading to a range of sequelae, including microcephaly, mental retardation, an