Original Paper Interaction of

estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity Valérie Guille1*, Andrea Gogos2,3*, Pradeep J Nathan4,5, Rodney J Croft1,6 and Maarten van den Buuse2,3 Estrogen may be involved in schizophrenia by inhibiting serotonin-1A (5-HT1A) receptor function. We examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (LDAEP) and mismatch negativity by the 5-HT1A receptor partial agonist, buspirone. Using a double-blind, placebo-controlled, repeated-measures design in healthy female volunteers, we observed that buspirone treatmen