Antimicrobial Susceptibility Patterns of Salmonella Typhi From Ki-

Background: Salmonellosis is a major health problem, especially in developing countries like Rwanda. Salmonella typhi infects only human and human transmission occur through feaco-oral route. Moreover, species are becoming resistant to the commonly used antibiotics. Objective: The aim of the present study is to know antimicrobial susceptibility patterns with special reference to multidrug resistance Salmonella enterica serovar Typhi and reduced susceptibility to nalidixic acid. Materials: A total 69 S.typhi isolated of King Faisal hospital, Kigali, Rwanda from stool and blood specimens were included in the study. Antimicrobial susceptibility was done by using Kirby-Bauer disc diffusion method. Results: There was decreased susceptibility was observed in Chloramphenicol, Ampicillin, Amoxycillin/Calvvlanic acid, Tetracycline, Cotrimoxazole and Nalidixic acid. These were sig-nificant increase in the multidrug resistant salmonella typhi (MRST) from 9.1 % to 25 % re-spectively between 2007 and 2008. All the isolates were 100 % sensitive to Ceftriaxone, Levofloxacin and Ciprofloxacin. Conclusion: Typhoid fever has been endemic in Kigali. Decreased susceptibility toward