Genome analysis SomaticSignatures: inferring mutational signatures from single-nucleotide variants

Summary: Mutational signatures are patterns in the occurrence of somatic single-nucleotide vari-ants that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable and easy-to-use tools that identify such signatures in cancer sequencing data. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements exist-ing methods for pattern decomposition, supports extension through user-defined approaches and integrates with existing Bioconductor workflows. Availability and implementation: The R package SomaticSignatures is available as part of the Bioconductor project. Its documentation provides additional details on the methods and demon-strates applications to biological datasets