Add to ORKGStem/progenitor cells are present in the adult brain; they undergo constant proliferation and differentiate into mature neurons in certain brain areas, a phenomenon called neurogenesis. This study investigated the effects of GDNF, a potent trophic factor of dopaminergic neurons, on neurogenesis in the brain. Nestin and 5-Bromo-2’-deoxyuridine (BrdU) were used as stem/progenitor cells markers. First, we observed extensive bilateral increases of stem/progenitor cells in the dentate gyrus and substantia nigra after continuous infusion of GDNF into the normal rat brain. However, none of the BrdU+ cells showed neuronal features in the substantia nigra as characterized by immunocytochemical procedures. Next, we identified the morphology of BrdU+ ...
<p>A–C: Confocal microscopic images immunohistochemically stained cells. A: BrdU positive cells. B: ...
AbstractThe locus coeruleus (LC), the main noradrenergic center in the brain, participates in many n...
ProBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is an important regulator of neuro...
Stem/progenitor cells are present in the adult brain; they undergo constantproliferation and differe...
This study investigated the ability of intra-subventricular zone (SVZ) administration of cerebral do...
<p>Neurospheres were immunostained with Ki67, nestin, DCX and GFAP antibodies to determine the effec...
Neural stem cell lines represent a homogeneous source of cells for genetic, developmental, and gene ...
Adult neurogenesis is a lifelong process that occurs in two main neurogenic niches of the brain, nam...
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor which has been pu...
To study how adult hippocampal neurogenesis might originate from the proliferation of stem or progen...
Background and Purpose-Stroke triggers increased progenitor proliferation in the subventricular zone...
The symptoms of Parkinson's disease occur due to degeneration of dopamine neurons in substantia nigr...
Many studies on neurogenesis in adult dentate gyrus (DG) have been performed on rodents and other ma...
[[abstract]]Neural stem cells generate a wide spectrum of cell types in developing and adult nervous...
Neural stem cells have become the focus of many studies as they have the potential to differentiate ...
<p>A–C: Confocal microscopic images immunohistochemically stained cells. A: BrdU positive cells. B: ...
AbstractThe locus coeruleus (LC), the main noradrenergic center in the brain, participates in many n...
ProBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is an important regulator of neuro...
Stem/progenitor cells are present in the adult brain; they undergo constantproliferation and differe...
This study investigated the ability of intra-subventricular zone (SVZ) administration of cerebral do...
<p>Neurospheres were immunostained with Ki67, nestin, DCX and GFAP antibodies to determine the effec...
Neural stem cell lines represent a homogeneous source of cells for genetic, developmental, and gene ...
Adult neurogenesis is a lifelong process that occurs in two main neurogenic niches of the brain, nam...
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor which has been pu...
To study how adult hippocampal neurogenesis might originate from the proliferation of stem or progen...
Background and Purpose-Stroke triggers increased progenitor proliferation in the subventricular zone...
The symptoms of Parkinson's disease occur due to degeneration of dopamine neurons in substantia nigr...
Many studies on neurogenesis in adult dentate gyrus (DG) have been performed on rodents and other ma...
[[abstract]]Neural stem cells generate a wide spectrum of cell types in developing and adult nervous...
Neural stem cells have become the focus of many studies as they have the potential to differentiate ...
<p>A–C: Confocal microscopic images immunohistochemically stained cells. A: BrdU positive cells. B: ...
AbstractThe locus coeruleus (LC), the main noradrenergic center in the brain, participates in many n...
ProBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is an important regulator of neuro...