Low Seroprotection against Preseasonal Influenza Local Strains in Children Might Predict the Upcoming Epidemic Influenza Strains

Background. Our objective was to determine the serological signals that indicated the possible dominant cir-culating influenza virus subtypes for the coming influenza seasons. Methods. Healthy children 6 months through 5 years of age, adults 18–60 years of age, and elderly adults 160 years of age were recruited to receive seasonal trivalent inactivated influenza vaccinations from October through December during the 2006–2007 and 2008–2009 seasons. Paired serum samples were collected at baseline and at 3 weeks after vaccination. Using a hemagglutination inhibition (HAI) assay, we measured antibody responses to local influenza strains circulating early in October, before each winter influenza season. Results. A total of 301 subjects were tested for antibody to local strains (80, 120, and 101 subjects in the 2006–2007, 2007–2008, and 2008–2009 seasons, respectively). The dominant winter influenza strains in Taiwan were B/Malaysia/2506/2004-like in the 2006–2007 season, A/Brisbane/59/2007-like virus (H1N1) in the 2007–2008 season, and A/Brisbane/59/2007-like virus (H1N1) in the 2008–2009 season. The group with the lowest number of subjects with an HAI titer of 40 at baseline was children with antibody against the B/Taiwan/0050/2006 in the 2006–2007 season, A/Taiwan/785/2006 (H1N1) in 2007–2008 season, and A/Taiwan/951/2007 (H1N1) in 2008– 2009 season. The emergence of these viruses correlated well with the circulating influenza subtype in the following winter peak seasons