Add to ORKGAbstract: Anti-TNFα therapy has revolutionized the treatment of rheumatoid arthritis (RA) and other infl ammatory diseases. These drugs are powerful and expensive. A new anti-TNFα agent, a nanomolecule comprising a humanized Fab ' antibody fragment against TNFα with a polyethylene glycol tail, is shortly to complete phase III trials in RA. In this review we will discuss the construct of this new molecule, data from trials so far, and its potential place in the market place
Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Tumor necrosis factor α (TNFα is a cytokine with many biological functions of relevance to inflammat...
Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment...
The development of effective new treatments is greatly facilitated by the understanding of the mecha...
Tumor necrosis factor (TNF)-α is a potent trimeric cytokine which plays a fundamental role in the ho...
While for a century therapeutics has been dominated by small molecules organic chemicals of ~ 400 da...
Rheumatoid arthritis (RA) is an immune-mediated condition which primarily affects the joints, but wi...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment...
ABSTRACTIt is now evident that biological agents targeting on the tumor necrosis factor (TNF) have n...
In 2020, the anti-tumor necrosis factor (TNF) monoclonal antibody Humira® generated US$165.8 billion...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
The convergence of three research pathways has led to the development of anew class of biological ag...
Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Tumor necrosis factor α (TNFα is a cytokine with many biological functions of relevance to inflammat...
Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment...
The development of effective new treatments is greatly facilitated by the understanding of the mecha...
Tumor necrosis factor (TNF)-α is a potent trimeric cytokine which plays a fundamental role in the ho...
While for a century therapeutics has been dominated by small molecules organic chemicals of ~ 400 da...
Rheumatoid arthritis (RA) is an immune-mediated condition which primarily affects the joints, but wi...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Progress in understanding mechanisms of disease are necessary to usher in major changes in treatment...
ABSTRACTIt is now evident that biological agents targeting on the tumor necrosis factor (TNF) have n...
In 2020, the anti-tumor necrosis factor (TNF) monoclonal antibody Humira® generated US$165.8 billion...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
The convergence of three research pathways has led to the development of anew class of biological ag...
Due to the key role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of immunoinflammatory...
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins wit...
Tumor necrosis factor α (TNFα is a cytokine with many biological functions of relevance to inflammat...