shown in Fig. 1. 1 (&) Personally examined

SUMMARY A family pedigree with a possible new genetic syndrome characterised by the presence of angiomas, systemic in nature, affecting particularly the skin and the central nervous system, is described. Angiomas of the CNS seem to have a marked tendency to bleed. The condition shows a clearly dominant mode of transmission, four subjects in three generations being affected. Differentiation from other conditions belonging to the vascular abnormalities subgroup of phakomatoses is presented. Most cases of vascular malformation, apart from several well known genetic conditions, occur sporadically and do not seem to be genetically deter-mined. Familial cases of syndromes like those of Sturge-Weber, Klippel-Trenaunay-Weber, and Bon-net-Dechaume-Blanc, as well as other forms of angiomatous changes, are exceptional. This was the main reason for describing a family in which angiomatous changes, not consistent with any recognised genetic syndrome, seem to show clear-cut Mendelian inheritance. The pedigree i