Published by Sciedu Press 1 ORIGINAL ARTICLE Endogenous Cushing’s syndrome: The Philippine

Background and significance: Endogenous Cushing's syndrome is a rare disease entity approximately 13 cases per million population. In Asia, and specifically in the Philippines, the exact incidence is unknown. As well, it's clinical presentation among Filipinos is not well described. The local epidemiology of obesity, diabetes and hypertension are different from other countries. These conditions are the usual initial differential diagnosis for Cushing's syndrome. This case collection is thus important for the awareness of clinicians on the clinical presentation and course of individuals with this condition. Methodology: Medical records of patients diagnosed with Endogenous Cushing’s Syndrome (non steroid-induced) within the year 2005-2011 were retrieved using the ICD 10 code for Cushing’s Syndrome (E24). Exogenous Cushing’s Syndrome (steroid-induced) were all excluded from the study. All selected medical records were individually reviewed, assessed and carefully recorded. Results: The study included 19 cases (8 pituitary adenoma, 7 adrenal adenoma, 4 ectopic adenoma) of endogenous Cushing’s Syndrome. Female predominance was noted. The most commonly reported clinical symptom and sign were weight gain and moon facies respectively. Short clinical course, hyperpigmentation, ecchymoses, behavioural changes and severe hypokalemia were observed to be more prominent among cases with ectopic sources. All cases had significantl