zin-3(2H)-one (E7016), an inhibitor of poly(ADP-ribose) polymerase, is being developed for anticancer therapy. One of the major me-tabolites identified in preclinical animal studies was the product of an apparent oxidation and ring opening of the 4-hydroxypiperidine. In vitro, this oxidized metabolite could not be generated by incu-bating E7016 with animal or human liver microsomes. Further stud-ies revealed the formation of this unique metabolite in hepato-cytes. In a NAD(P)-dependent manner, this metabolite was also generated by liver S9 fractions and recombinant human flavin-containing monooxygenase (FMO) 5 that was fortified with liver cytosol fractions. In animal and human liver S9, this metabolic pathway could be inhibited by 4-methyl...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antipara...
Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised ...
Flavin-containing mono-oxygenases are known as potent drug metabolizing enzymes, providing complemen...
BYZX, [(E)-2-(4-((diethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one], belongs to a...
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor...
5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor agent that is also acti...
Flavin-containing monooxygenases (FMOs) are emerging as effective players in oxidative drug metaboli...
Baeyer-Villiger monooxygenases (BVMOs) are enzymes that catalyze the oxidation of ketones to esters....
Two-component flavoprotein monooxygenases consist of a reductase and an oxygenase enzyme. The proof ...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
International audienceTwo-component flavoprotein monooxygenases consist of a reductase and an oxygen...
Flavin-containing mono-oxygenases are known as potent drug-metabolizing enzymes, providing complemen...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antipara...
Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised ...
Flavin-containing mono-oxygenases are known as potent drug metabolizing enzymes, providing complemen...
BYZX, [(E)-2-(4-((diethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one], belongs to a...
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor...
5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor agent that is also acti...
Flavin-containing monooxygenases (FMOs) are emerging as effective players in oxidative drug metaboli...
Baeyer-Villiger monooxygenases (BVMOs) are enzymes that catalyze the oxidation of ketones to esters....
Two-component flavoprotein monooxygenases consist of a reductase and an oxygenase enzyme. The proof ...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
International audienceTwo-component flavoprotein monooxygenases consist of a reductase and an oxygen...
Flavin-containing mono-oxygenases are known as potent drug-metabolizing enzymes, providing complemen...
Baeyer-Villiger monooxygenases catalyze the oxidation of carbonylic substrates to ester or lactone p...
DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antipara...
Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised ...