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The Supplemental Instruction (SI) model of student academic assistance helps students master classes that have a history of a high degree of difficulty as they develop and integrate learning and study strategies. This paper reviews research on SI, developed at the University of Missouri-Kansas City, which has been selected as an Exemplary Educational Program by the U.S. Department of Education. The SI program is used by faculty who teach courses that have been identified as high risk (30 % failure rate or higher). An SI leader provides three to five SI lessons out of class each week. The paper reviews the effectiveness of the SI program, discusses its specific features, and reviews program costs. It also reports on the results of six studies of SI at the University of Missouri and other locations. Results of these studies indicate that the program has positive effects on course grades, re-enrollment rates, and graduate rates across racial and ethnic groups. (Contains 32 references.) (SLD) Reproductions supplied by EDRS are the best that can be mad