Add to ORKGI want to thank to my adviser, Dr. Uli Munderloh, for all these years that she has helped me to become a better researcher. Her guidance and encouragement is what has helped me to finish. I am very thankful with Dr. Kurtti as well. His kindness and advice was also essential to get through all the hard days. I want to thank my committee members Dr. Fallon and Dr. Redig for their help and revisions of this document. I also want to recognize Nicole, Rod, Curt, and Mike who helped me endlessly with my research, teaching me techniques and how to do things. I know I am a thick head and sometimes it may have been hard. I want to thank Kendra, Bryten, Chan, Jon, Hyo, and Geoff for help and a precious friendship in the lab. I will miss you guys once...