ii ACKOWLEDGEMENTS There are few times in a person's life when she has the opportunity to work with such a wonderful man as Dr. Bob Cone. He not only demonstrated extraordinary patience with me during my research training but he also provided me with a wealth of knowledge and emotional support. I thoroughly enjoyed working in his lab and I will forever remember that he introduced me to research in immunology. I would also like to thank Dr. Clarence Trummel who was an Associate Advisor for my masters committee and the Chairman of Periodontology. He continually demonstrated understanding and lended support to his residents. I am also grateful to Dr. Chi-Kuang Huang, who served on my thesis committee and provided me with helpful hints dur...