OBJECTIVE—The catabasis of inflammation is an active pro-cess directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RESEARCH DESIGN AND METHODS—We used transgenic expression of the fat-1 n-3 fatty acid desaturase from C. elegans to endogenously restore n-3 fatty acids in HF-fed mice. After 8 weeks on HF or chow diets, wild-type and fat-1 transgenic mice were subjected to insulin and glucose tolerance tests and a resolution assay was performed. Metabolic tissues were then harvested for biochemical analyses. RESULTS—We report that the n-3 docos...
Open URL - http://www.endojournals.org/site/abstracts/P1-1_to_P1-729.pdfINTRODUCTION: Obesity caused...
Abstract Background Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert ...
In studies emphasizing antiobesogenic and anti-inflammatory effects of long-chain n-3 polyunsaturate...
The role of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in the regulation of energy homeostasis ...
OBJECTIVE—To evaluate the direct impact of n-3 polyunsatu-rated fatty acids (n-3 PUFAs) on the funct...
Calorie restriction is an essential component in the treatment of obesity and associated diseases. L...
NoBecause of confounding factors, the effects of dietary n-3 polyunsaturated fatty acids (PUFA) on t...
The objective of this study was to investigate the impact of elevated tissue omega-3 (n-3) polyunsat...
Obesity is characterized by profound alterations in adipose tissue (AT) biology, leading to whole bo...
BACKGROUND: Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert multiple...
AIMS/HYPOTHESIS: Inflammation in obesity increases the levels of the suppressor of cytokine signalli...
The fat-1 transgenic mice were used as models, to investigate the effects of n-3PUFAs on body weight...
Obesity and insulin resistance are associated with increased serum free fatty acids (FFAs). Thus, a ...
Adipose tissue and its hormones have an irreplaceable role in the physiology of mammals. The imbalan...
Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes f...
Open URL - http://www.endojournals.org/site/abstracts/P1-1_to_P1-729.pdfINTRODUCTION: Obesity caused...
Abstract Background Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert ...
In studies emphasizing antiobesogenic and anti-inflammatory effects of long-chain n-3 polyunsaturate...
The role of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in the regulation of energy homeostasis ...
OBJECTIVE—To evaluate the direct impact of n-3 polyunsatu-rated fatty acids (n-3 PUFAs) on the funct...
Calorie restriction is an essential component in the treatment of obesity and associated diseases. L...
NoBecause of confounding factors, the effects of dietary n-3 polyunsaturated fatty acids (PUFA) on t...
The objective of this study was to investigate the impact of elevated tissue omega-3 (n-3) polyunsat...
Obesity is characterized by profound alterations in adipose tissue (AT) biology, leading to whole bo...
BACKGROUND: Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert multiple...
AIMS/HYPOTHESIS: Inflammation in obesity increases the levels of the suppressor of cytokine signalli...
The fat-1 transgenic mice were used as models, to investigate the effects of n-3PUFAs on body weight...
Obesity and insulin resistance are associated with increased serum free fatty acids (FFAs). Thus, a ...
Adipose tissue and its hormones have an irreplaceable role in the physiology of mammals. The imbalan...
Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes f...
Open URL - http://www.endojournals.org/site/abstracts/P1-1_to_P1-729.pdfINTRODUCTION: Obesity caused...
Abstract Background Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert ...
In studies emphasizing antiobesogenic and anti-inflammatory effects of long-chain n-3 polyunsaturate...