Avogaro A. Significance of endothelial progenitor cells in subjects with diabetes. Diabetes Care

D iabetes complications represent ahuge burden for patients and healthservices. The fight against each sin-gle complication has led to significant im-provements in diabetes care, especially formicrovascular complications, yetmac-roangiopathy remains a major source of morbidity and mortality. A common ap-proach for the prevention and treatment of diabetes complications relies on the un-derstanding of their complex pathophys-iology. A unifying biochemical theory suggests that oxidative stress underlies subsequent cellular damage pathways, which leads to diabetes complications, but common supracellular mechanisms are still unclear. Endothelial progenito