THIOCYANATE GOITER IN MAN*

T H A T a definite relationship exists between iodine deficiency and many non-toxic goiters is well established. Indeed endemic goiter is usually, and perhaps too readily, accepted as being due to iodine deficiency. Experi-mentally, thyroid hyperplasia has been produced in various laboratory ani-mals by many goitrogenic agents other than iodine deficient diets. Astwood, et al.1 in a recent report, referred to extensive literature on a variety of goitrogens. Some of the most interesting studies in goitrogenesis were incited by observations made by Chesney, Clawson and Webster 2 ' 3 ' 4 in 1928. They observed large hyperplastic goiters in rabbits maintained on cabbage diets. In spite of the fact that these thyroids showed extreme hyperplasia, the ani-mals were found to have low metabolic rates. Though the goiters could be prevented by administering iodine, if iodine was given after the goiter had developed, a severe thyrotoxicosis ensued promptly. Marine, Baumann, Spence and Cipra 5 confirmed this work and also found that the leaves o