Some Metabolic interrelationships of Folic Acid, Vitamin B12, and Ascorbic Acid

J N THE field of vitamin research it is doubt-ful if there lmas been more apparently contradictory I)ubhishled research than that concerning time roles of folic acid and vitamin B12 in metabolism. The reason for this state of affairs is not clear, unless it can be attributed to slight variations in experi-mental approach from one laboratory to an-other. Minor changes in apparently unim-portant nutrients, differences in management of animals, differences in types of the or-ganisms, tissue or organ studied: all of these could account to some extent for the differences of opinion concerning the mechanism of ac-tion of folic acid and particularly of vitami