Electronic letter

Familial craniofacial fibrous dysplasia: absence of linkage to GNAS1 and the gene for cherubism EDITOR—Fibrous dysplasia is a benign fibro-osseous condition that may involve one or more bones in the cranial and extracranial skeleton. There are four main types of fibrous dysplasia: monostotic in which only one bone is aVected1; polyostotic in which multiple bones are aVected2; McCune-Albright syndrome (MIM 174800), a polyostotic form accompanied by pigmentation lesions and endocrine dysfunction presenting as precocious puberty in females3 4; and a craniofacial form (CFD) in which only bones of the craniofacial complex are aVected.5 The majority of patients with CFD present in their second decade; the lesions are generally unilateral and tend to become static once skeleta