Add to ORKGEffects of pimaric acid (PiMA) and eight closely related com-pounds on large-conductance K (BK) channels were exam-ined using human embryonic kidney (HEK) 293 cells, in which either the subunit of BK channel (HEKBK) or both and 1 (HEKBK1) subunits were heterologously expressed. Effects of these compounds (10 M) on the membrane potential of HEKBK1 were monitored by use of DiBAC4(3), a voltage-sensitive dye. PiMA, isopimaric acid, sandaracoisopimaric acid, dihydropimaric acid, dihydroisopimaric acid, and dihydroisopi-marinol induced substantial membrane hyperpolarization. The direct measurement of BK1 opening under whole-cell volt-age clamp showed that these six compounds activated BK1 in a very similar concentration range (1–10 M); in con...
[[abstract]]AIM: In this study, we examine whether an anti-inflammatory thiourea derivative, compoun...
Background and purpose: Kaempferol has been shown to possess a vasodilator effect but its mechanism ...
Potassium channels are ubiquitous proteins that selectively allow potassium ions across the cell mem...
1. Currents through large conductance calcium-activated potassium channels were recorded using path...
Large conductance calcium activated potassium channels (BKCa) are fundamental in the control of cell...
[[abstract]]1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) is reported to be an activato...
Because of the physiological role played by the hyperpolarisation process resulting from a K(+) outf...
The large-conductance Ca2+-activated K+ channel (BKCa channel) is involved in repolarizing the membr...
The assembly of voltage-gated potassium (Kv) channels with subunits modifies the electrophysiologic...
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabo-lites of cytochrome P450 monooxygenase,...
Ion channels are membrane proteins that regulate the permeability of ions across the cell membrane. ...
Large conductance, calcium- and voltage-activated potassium (BK Ca) channels are important modulator...
Large-conductance calcium-activated potassium channels, also known as BK or Maxi-K channels, occur i...
Fatty acids and other negatively charged single-chain lipids increase large-conductance Ca(2+)-activ...
The effects of a novel vasorelaxant agent, MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobu...
[[abstract]]AIM: In this study, we examine whether an anti-inflammatory thiourea derivative, compoun...
Background and purpose: Kaempferol has been shown to possess a vasodilator effect but its mechanism ...
Potassium channels are ubiquitous proteins that selectively allow potassium ions across the cell mem...
1. Currents through large conductance calcium-activated potassium channels were recorded using path...
Large conductance calcium activated potassium channels (BKCa) are fundamental in the control of cell...
[[abstract]]1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) is reported to be an activato...
Because of the physiological role played by the hyperpolarisation process resulting from a K(+) outf...
The large-conductance Ca2+-activated K+ channel (BKCa channel) is involved in repolarizing the membr...
The assembly of voltage-gated potassium (Kv) channels with subunits modifies the electrophysiologic...
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabo-lites of cytochrome P450 monooxygenase,...
Ion channels are membrane proteins that regulate the permeability of ions across the cell membrane. ...
Large conductance, calcium- and voltage-activated potassium (BK Ca) channels are important modulator...
Large-conductance calcium-activated potassium channels, also known as BK or Maxi-K channels, occur i...
Fatty acids and other negatively charged single-chain lipids increase large-conductance Ca(2+)-activ...
The effects of a novel vasorelaxant agent, MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobu...
[[abstract]]AIM: In this study, we examine whether an anti-inflammatory thiourea derivative, compoun...
Background and purpose: Kaempferol has been shown to possess a vasodilator effect but its mechanism ...
Potassium channels are ubiquitous proteins that selectively allow potassium ions across the cell mem...