Supervisors

The non-classical HLA class Ib genes, HLA-E,-F, and-G, are the only HLA genes found to be expressed in trophoblast cells in the placenta along with low expression of HLA-C. HLA-G, which is the best studied of the non-classical HLA class Ib molecules, has been found to be implicated in pregnancy complications due to its immunomodulatory function at the feto-maternal interface. As the structure and expression of HLA-F resemble that of the other class Ib molecules, especially HLA-G, it is hypothesized that it might also play an important immunological role during pregnancy. The aim of this case-control study is to examine the possible immunological association between polymorphisms in the HLA-F gene and Recurrent Spontaneous Abortions. In order to elucidate this hypothesis, polymerase chain reaction (PCR) amplifications of the 5 ’ URR and 3 ’ UTR of HLA-F from DNA samples derived from RSA patients and a control group are conducted and compared. Abstrakt De nonklassiske HLA klasse Ib gener, HLA-E,-F, and-G er de eneste HLA gener, der udtrykkes i trophoblastceller i placenta sammen med et lavt udtryk af HLA-C. HLA-G, som er det beds