Add to ORKGThe G2019S leucine-rich repeat kinase 2 gene (LRRK2) mutation has been identified in a significant proportion of familial and sporadic cases of Parkinson’s disease (PD). Until now, information on the neuropathological changes associated with the G2019S LRRK2 mutation has been sparse. We report a 77-year-old patient who presented with a 14 year history of PD but, unexpectedly, histopathological examination disclosed mild neuronal loss in the substantia nigra without a-synuclein, tau or ubiquitin cytoplasmic inclusions. A G2019S LRRK2 mutation was eventually detected. The present case confirms that clinical PD caused by G2019S mutations can be associated with non-specific nigral degeneration without Lewy bodies. R ecently, pathogenic mutation...
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (<i>LRRK2</i>), which c...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Abstract Leucine-rich repeat kinase 2 (LRRK2) is the most common causative gene for autosomal domina...
Mutations in Leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of sporadic and fam...
The identification of the leucine-rich repeat kinase 2 (LRRK2) gene was a breakthrough in the area o...
There is increasing evidence of genetic contribution to the pathogenesis of Parkinson’s disease. The...
•- The authors have no financial conflicts of interest. Copyright © 2010 The Korean Movement Disorde...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have emerged as a potential common cause ...
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucin...
The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh ...
Parkinson’s disease (PD) is a debilitating and progressive neurodegenerative disorder that affects o...
Background Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosom...
Background and PurposeaaThe LRRK2 (PARK8; OMIM607060) substitution was recently identified as a caus...
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (<i>LRRK2</i>), which c...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Abstract Leucine-rich repeat kinase 2 (LRRK2) is the most common causative gene for autosomal domina...
Mutations in Leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of sporadic and fam...
The identification of the leucine-rich repeat kinase 2 (LRRK2) gene was a breakthrough in the area o...
There is increasing evidence of genetic contribution to the pathogenesis of Parkinson’s disease. The...
•- The authors have no financial conflicts of interest. Copyright © 2010 The Korean Movement Disorde...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have emerged as a potential common cause ...
Autosomal dominant parkinsonism has been attributed to pathogenic amino acid substitutions in leucin...
The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh ...
Parkinson’s disease (PD) is a debilitating and progressive neurodegenerative disorder that affects o...
Background Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosom...
Background and PurposeaaThe LRRK2 (PARK8; OMIM607060) substitution was recently identified as a caus...
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (<i>LRRK2</i>), which c...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Pa...