Familial Felty's syndrome

which the mother and 2 of the 5 children had Felty's syndrome, a pattern of inheritance suggesting a dominant defect and one which has not previously been reported. The family is also of interest in that the other sib had rheumatoid arthritis. In 1924, Felty first reported splenomegaly and neutropenia occurring in 5 patients with rheumatoid arthritis. Since then many series of patients with this syndrome have been described (De Gruchy an