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PURPOSE: This retrospective study was conducted to follow out acute intoxications with neuroleptics in Varna region, to assess the frequency and proportion depending on other drug and non-pharmacological poisonings. METHODS: The objects of the study are 193 patients with acute neuroleptic intoxications treated in the Clinic of toxicology of the Military Medical Academy – Varna, Bulgaria. The study is retrospective and cov-ers a period of 20 years (1991-2010). RESULTS: The incidence of acute poisonings with neuroleptics was 7.5 % of all drug poisonings and 2.5% of general poisonings. Poisoning occurs more commonly in women and the majority of poisonings were in people of working age. CONCLUSION: In recent years, there is a trend for an increase in the absolute number and the proportion of poisonings with neuroleptics. Lethality in these poisonings is not high – 0.4 percent