Class 1

Mast cells are effector cells of the immune system that are derived from hemato-poietic stem cells.1,2 These cells regulate both innate and adaptive immunity and have also been implicated in a variety of inflammatory diseases.1,2 The matura-tion of these cells is dependent on signals regulated via the c-Kit and IL-3 receptors as well as transcription factors including MITF.1-3 While the role of c-Kit and IL-3 receptor in mast development is known; the signaling molecules downstream from these receptors involved in regulating the growth and maturation of these cells are poorly understood