RESEARCH ARTICLE Open Access l

Full list of author information is available at the end of the articleBackground Patients with diabetes mellitus have a high risk of ather-othrombotic events. Many studies have shown a variety of diabetes mellitus related abnormalities in hemostasis and thrombosis [1,2]. The diabetic condition contributes for initiation and progression of microvascular and macro-vascular complications [3]. Although modern coagulation diagnostic tests are be-coming more sophisticated, standard coagulation screening tests, such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) are still important basic exami-nations in clinical laboratories. Shortened aPTT values may reflect a hypercoaguable state, which is potentially associ-ated with increased thrombotic risk and adverse cardiovas-cular events [4,5]. Shortened aPTT may result from an accumulation of circulating activated coagulation factors in * Correspondence