1Arnold, et al: Duloxetine and patient improvement Personal non-commercial use only. The Journal of Rheumatology Copyright © 2010. All rights reserved. Flexible Dosed Duloxetine in the Treatment of Fibromyalgia: A Randomized, Double-blind,

ABSTRACT. Objective. To investigate the efficacy of flexible dose duloxetine 60–120 mg/day on changes in fibromyalgia (FM) symptoms assessed by the Patient Global Impression of Improvement (PGI-I) scale. Methods. Outpatients ≥ 18 years of age who met American College of Rheumatology criteria for FM, and had ≥ 4 score on the Brief Pain Inventory (BPI) average pain item, were randomized to duloxetine (n = 263) or placebo (n = 267) for 24 week double-blind treatment (primary endpoint at Week 12). Key secondary measures included BPI average pain severity, patient-rated scales assess