Diverse roles in DNA metabolism have been envisaged for budding yeast and mammalian Rif1. In particular, yeast Rif1 is involved in telomere homeostasis, while its mammalian counterpart partici-pates in the cellular response to DNA double-strand breaks (DSBs). Here, we show that Saccharomyces cerevisiae Rif1 supports cell survival to DNA lesions in the absence of MRX or Sae2. Further-more, it contributes to the nucleolytic processing (resection) of DSBs. This Rif1-dependent control of DSB resection becomes important for DSB repair by homologous recombination when resection activities are suboptimal
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability a...
Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromos...
SummaryThe Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently b...
Diverse roles in DNA metabolism have been envisaged for budding yeast and mammalian Rif1. In particu...
<div><p>The cellular response to DNA double-strand breaks (DSBs) is initiated by the MRX/MRN complex...
Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear ...
In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chr...
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) ...
Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Exami...
AbstractDNA double strand breaks (DSBs) are highly toxic to the cells and accumulation of DSBs resul...
Ph. D. Thesis.The response to DNA damage is imperative to deciding the future of a cell. Damage need...
Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserve...
PhD Thesis. Figures referred to can be found at the end of the text.Telomeres cap the end of linear...
International audienceSpecific proteins present at telomeres ensure chromosome end stability, in lar...
Specific proteins present at telomeres ensure chromosome end stability. In this work, we address ho...
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability a...
Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromos...
SummaryThe Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently b...
Diverse roles in DNA metabolism have been envisaged for budding yeast and mammalian Rif1. In particu...
<div><p>The cellular response to DNA double-strand breaks (DSBs) is initiated by the MRX/MRN complex...
Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear ...
In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at chr...
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) ...
Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Exami...
AbstractDNA double strand breaks (DSBs) are highly toxic to the cells and accumulation of DSBs resul...
Ph. D. Thesis.The response to DNA damage is imperative to deciding the future of a cell. Damage need...
Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserve...
PhD Thesis. Figures referred to can be found at the end of the text.Telomeres cap the end of linear...
International audienceSpecific proteins present at telomeres ensure chromosome end stability, in lar...
Specific proteins present at telomeres ensure chromosome end stability. In this work, we address ho...
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability a...
Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromos...
SummaryThe Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently b...