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2 Background: There is ongoing conjecture over whether childhood immunisation leads to an increased risk of developing atopic diseases. Objective: To examine associations between childhood immunisation and the risk of atopic disease. Methodology: Immunisation histories of 8,443 Tasmanian children born in 1961 obtained from School Medical Records were linked to the Tasmanian Asthma Study. Associations between immunisation status and atopic diseases were examined while adjusting for possible confounders using multiple logistic regression. Results: Diphtheria immunisation was weakly associated with an increased risk of asthma by age 7 years (OR 1.3, 95 % CI 1.1-1.7), but there was no evidence of any association for four othe