RESEARCH ARTICLE MicroRNA-27a promotes p

Full list of author information is available at the end of the articleLaryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancers in the world. In China, the incidence of LSCC has been rising gradually, especially in the northeast part. The potentially high in-cidence of morbidity and incommensurably low cure rate, as expected, require searching for new diagnostic procedures and carcinogenic factors of LSCC [1-3]. laryngeal cancer, there are no ideal biomarkers for the de-termination of prognosis and the guidance of treatment in laryngeal cancer patients. Presently, much work is focused on the identification of useful biologic and molecular markers in the diagnosis and therapy of LSCC [4,5]. MicroRNAs (miRNAs), a 20–23 nt functional RNA molecule, are a class of short non-coding RNAs and play important regulatory roles by sequence-specific base pairing on the 3 ′ untranslated region (3′-UTR) of target messenger RNAs (mRNAs), in promoting mRNA deg-radation or inhibiting translation [6]. Increasing evidenc