Mazaahir Kidwai,

Since the appearance of the first paper on the application of microwave irradiation in the chemical synthesis 1 the approach has blossomed into a useful technique for a variety of applications in organic synthesis 2 and functional group transformations. 3 In moving towards sustainable techno-logies the focus has now shifted to less cumbersome solvent-less methods wherein solid supported 4 microwave synthe-sis 5,6 has played an important role. This technique eliminates the use of solvent during the reaction stage but requires an appreciable amount of solvent for the adsorption of reagents and elution of product. The emergence of neat reaction is a recent approach under the new paradigm of green chemistry 7 where the neat reactants undergo facile reaction to provide high yield of pure products thus eliminating or minimizing the use of organic solvents. These no solvent 8 reactions are not only advantageous for environmental reasons but also offer benefits of enhanced reaction rates, greater selectivity and experimental ease of manipulation. The imidazole ring system is of particular interest as it is a component of histidine that produces histamine in metabolic process. 9 The potency and wide applicability of the imidazole pharmacophore can be attributed to its hydrogen bond donor-acceptor capability as well as its high affinity for metals which are present in many protein active sites (eg