Brief Definit ive Report

The dysregulated activation and expansion of CD4+ T cells lie at the core of autoimmune dis-orders. It is now widely recognized that TH17 cells, a subset of T helper cells which produce IL-17A, IL-17F, IL-21, IL-22, and GM-CSF, mediate autoimmune conditions including mul-tiple sclerosis, psoriasis, rheumatoid arthritis, and Crohn’s disease, as well as the murine models of these diseases (Bettelli et al., 2006; Korn et al., 2009; Littman and Rudensky, 2010). To differ