ORIGINAL ARTICLE Consuming a multi-ingredient thermogenic supplement for 28 days is apparently safe in healthy adults

Background: Thermogenic (TRM) supplements are often used by people seeking to decrease body weight. Many TRM supplements are formulated with multiple ingredients purported to increase energy expenditure and maximize fat loss. However, in the past some TRM ingredients have been deemed unsafe and removed from the market. Therefore, it is important to verify the safety of multi-ingredient TRM supplements with chronic consumption. Objective: To assess the safety of daily consumption of a multi-ingredient TRM supplement over a 28-day period in healthy adults. Design: Twenty-three recreationally active adults (11M, 12F; 27.195.4 years, 171.699.6 cm, 76.8916.1 kg, 2695 BMI) were randomly assigned either to consume a multi-ingredient TRM supplement (SUP; n9) or remain unsupplemented (CRL; n14) for 28 days. Participants maintained their habitual dietary and exercise routines for the duration of the study. Fasting blood samples, resting blood pressure, and heart rate were taken before and after the supplementation period. Samples were analyzed for complete blood counts, comprehensive metabolic, and lipid panels. Results: Significant (pB0.05) group by time interactions were present for diastolic BP, creatinine, esti