RESEARCH ARTICLE Adipokines and the Right Ventricle: The MESA-RV Study

Objective Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipo-kine levels were associated with RV morphology and function in a population-based multi-ethnic sample free of clinical cardiovascular disease. Methods We examined relationships of leptin, resistin, TNF-α, and adiponectin with RV morphology and function (from cardiac MRI) in participants (n = 1,267) free of clinical cardiovascular dis-ease from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study. Multivariable regres-sions (linear, quantile [25th and 75th] and generalized additive models [GAM]) were used to examine the independent association of each adipokine with RV mass, RV end-diastolic volume (RVEDV), RV end-systolic volume (RVESV), RV stroke volume (RVSV) and RV ejection fraction (RVEF). Result