Hemolytic Anemia Induced by Dapsone Transmitted Through Breast Milk

treat several dermatologic disorders (1) including der-matitis herpetiformis. Due to the chronicity of dermatitis herpetiformis and its frequent onset from age 20 to 40 years, therapy with dapsone may coincide with pregnan-cy and lactation. We describe an infant who had signifi-cant serum concentrations of dapsone and its primary metabolite, monoacetyldapsone, after ingesting breast milk containing dapsone. Both the mother and infant had compensated hemolytic anemia. Dapsone and monoacetyldapsone were analyzed by high pressure liquid chromatography using a modification of the method of Carr and associates (2). Recrystallized 3,3'-diamino