RESEARCH ARTICLE h Age-related macular degeneration (AMD) is a major cause features and treatment guidelines are somewhat differ-

terised by typical choroidal neovascularisation (CNV) that can cause severe vision loss [2]. Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy marked by branching networks of inner choroidal vessels and a nodular appearance on stereoscopic view with indocyanine green angiography (ICGA) [3]. Emerging evidence has shown that PCV is more common in Asians than in Caucasians [4,5], and it has been recognised as a special ent. Although nAMD and PCV share some common genetic determinants, such as the complement factor H gene (CFH) and the high temperature requirement factor A1 (HTRA1) gene [8,9], they are not the same. For ex-ample, superkiller viralicidic activity 2-like (SKIV2 L), in the entire C2 (complement component 2)-CFB (com-plement factor B)-RDBP (RD RNA-binding protein)-SKIV2 L region, is associated with nAMD but not with PCV [10]. The rs5882 near cholesteryl ester transfer protein (CETP) is significantly associated with PCV but not with nAMD [11]. Growth differentiation factor 6 (GDF6) is a member of * Correspondence