Add to ORKGwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The development of multiple antibiotic resistance is a global problem. It is necessary to find new tools whose mechanisms of action differ from those of currently used antibiotics. It is known that fatty acids and cationic polypeptides are able to fight bacteria. Here, we describe the synthesis of fatty acids linked to a polypeptide with antibacterial activity.The linkage of fatty acids to a polypeptide is reported to increase the antibacterial effect of the linked fatty acid in comparison with free fatty acids (FA) or free poly-L-lysine (PLL) or amixture of both (FA free + PLL free). A number of C 6 –
The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a majo...
International audienceThe spread of new strains of antibiotic-resistant pathogenic microorganisms ha...
Lipopolysaccharides (LPSs), which constitute the lipid portion of the outer leaflet of Gram-negative...
Antibiotics are among the most frequently prescribed medications in current medicine, however there ...
Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to ki...
Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to ki...
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by ...
The antimicrobial effects of free fatty acids are well recognised and these compounds can prevent th...
As more and more bacteria become resistance against the drugs currently used in the clinic we are in...
Abstract Background As a natural antibacterial cationic peptide, ε-poly-l-lysine (ε-PL) is applied a...
Antimicrobial peptides (AMPs) are a family of tiny peptides found throughout nature that play a vita...
Antibiotic resistance has been an emerging threat to the public health. Since the discovery of penic...
Bacterial resistance towards antibiotics is a major global health issue. Very few novel antimicrobia...
The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a majo...
International audienceThe spread of new strains of antibiotic-resistant pathogenic microorganisms ha...
Lipopolysaccharides (LPSs), which constitute the lipid portion of the outer leaflet of Gram-negative...
Antibiotics are among the most frequently prescribed medications in current medicine, however there ...
Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to ki...
Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to ki...
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by ...
The antimicrobial effects of free fatty acids are well recognised and these compounds can prevent th...
As more and more bacteria become resistance against the drugs currently used in the clinic we are in...
Abstract Background As a natural antibacterial cationic peptide, ε-poly-l-lysine (ε-PL) is applied a...
Antimicrobial peptides (AMPs) are a family of tiny peptides found throughout nature that play a vita...
Antibiotic resistance has been an emerging threat to the public health. Since the discovery of penic...
Bacterial resistance towards antibiotics is a major global health issue. Very few novel antimicrobia...
The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a majo...