The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in

production defect was associated with the deregulation of genes controlling cell proliferation and the cell fate. Using an immortalized human granulosa cell line, SVOG3e, we determined that the D1709N-DICER1 hotspot mutati the expression of several genes that control gonadal diffe wth. Re-expression of let-7 significantly inhibited the grow the suppression of key regulators of cell cycle control a data revealed that DICER1 hotspot mutations cause syste iffer-entiation of testicular elements and cause oncogeni