Background: Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway exhibits a similar ion transport defect as the lung, and colonization, infection, and inflammation within the nasal passages are common among CF patients. Nasal lavage fluid (NLF) is a minimally invasive means to collect upper airway samples. Methods: We collected NLF at the onset and resolution of CF APE and compared a 27-plex cytokine profile to stable CF outpatients and normal controls. We also tested IP-10 levels in the bronchoalveolar lavage fluid (BALF) of CF patients. Well-differentiated murine sinonasal monolayers were exposed to bacterial stimulus, and IP-10 levels were measured to test epithelial secretion. Results: Subjec...
Cystic Fibrosis (CF) lung disease is characterized by high levels of cytokines and chemokines in the...
Introduction : Pseudomonas aeruginosa pulmonary infections are the primary cause of morbi-mortality ...
Pulmonary exacerbations (PEs) cause significant morbidity and can severely impact disease progressio...
Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway ex...
Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway ex...
Background: Because persistent inflammation plays a dominant role in cystic fibrosis (CF), we assess...
BackgroundIn cystic fibrosis (CF), acute respiratory exacerbations critically enhance pulmonary dest...
Background: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well charac...
Background: Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammat...
BACKGROUND: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well charac...
Background: In adults with cystic fibrosis (CF), induced sputum (IS) is a minimally invasive alterna...
Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the...
Background and objective: In cystic fibrosis (CF) very few studies have assessed sputum 8-iso-PGF le...
Various treatment regimens and difficulties with research design are encountered with cystic fibrosi...
Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the...
Cystic Fibrosis (CF) lung disease is characterized by high levels of cytokines and chemokines in the...
Introduction : Pseudomonas aeruginosa pulmonary infections are the primary cause of morbi-mortality ...
Pulmonary exacerbations (PEs) cause significant morbidity and can severely impact disease progressio...
Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway ex...
Cystic fibrosis (CF) is characterized by acute pulmonary exacerbations (APE). The CF nasal airway ex...
Background: Because persistent inflammation plays a dominant role in cystic fibrosis (CF), we assess...
BackgroundIn cystic fibrosis (CF), acute respiratory exacerbations critically enhance pulmonary dest...
Background: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well charac...
Background: Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammat...
BACKGROUND: Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well charac...
Background: In adults with cystic fibrosis (CF), induced sputum (IS) is a minimally invasive alterna...
Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the...
Background and objective: In cystic fibrosis (CF) very few studies have assessed sputum 8-iso-PGF le...
Various treatment regimens and difficulties with research design are encountered with cystic fibrosi...
Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the...
Cystic Fibrosis (CF) lung disease is characterized by high levels of cytokines and chemokines in the...
Introduction : Pseudomonas aeruginosa pulmonary infections are the primary cause of morbi-mortality ...
Pulmonary exacerbations (PEs) cause significant morbidity and can severely impact disease progressio...