PaPer TyPe

auThOr’s vIew Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for the development of most solid tumors. While angiogenesis in normal tis-sues is tightly coordinated by the activity of various anti- and pro-angiogenic fac-tors, the formation of new blood vessels within neoplastic lesions is sustained by the imbalanced expression of pro-angio-genic mediators.1 This generally involves a functional interplay between malignant cells and several of their non-malignant counterparts that populate the tumor microenvironment, including endothelia