Add to ORKGThe conserved role of Notch signaling in controlling intestinal cell fate specification and homeostasis has been extensively studied. Nevertheless, the precise identity of the cells in which Notch signaling is active and the role of different Notch receptor paralogues in the intestine remain ambiguous, due to the lack of reliable tools to investigate Notch expression and function in vivo. We generated a new series of transgenic mice that allowed us, by lineage analysis, to formally prove that Notch1 and Notch2 are specifically expressed in crypt stem cells. In addition, a novel Notch reporter mouse, Hes1-EmGFPSAT, demonstrated exclusive Notch activity in crypt stem cells and absorptive progenitors. This roster of knock-in and reporte
Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and pr...
: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focu...
Copyright © The Histochemical SocietyThe Notch signaling pathway has become recognized as a vitally ...
The conserved role of Notch signaling in controlling intestinal cell fate specification and homeosta...
The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supp...
The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal c...
BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of p...
AbstractThe Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem...
International audienceColon tumours are hierarchically organized and contain multipotent self-renewi...
Proper organ homeostasis requires tight control of adult stem cells and differentiation through the ...
SummaryProper organ homeostasis requires tight control of adult stem cells and differentiation throu...
In the past decade, enormous progress has been made in understanding the role of stem cells in physi...
Throughout the lifetime of an organism, progenitor cells in the intestine proliferate and differenti...
The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem and ...
The gastric epithelium is sustained by a population of stem cells that replenish the various mature ...
Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and pr...
: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focu...
Copyright © The Histochemical SocietyThe Notch signaling pathway has become recognized as a vitally ...
The conserved role of Notch signaling in controlling intestinal cell fate specification and homeosta...
The mammalian intestine is a prototype of a self-renewing organ. The rapid cellular turnover is supp...
The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal c...
BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of p...
AbstractThe Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem...
International audienceColon tumours are hierarchically organized and contain multipotent self-renewi...
Proper organ homeostasis requires tight control of adult stem cells and differentiation through the ...
SummaryProper organ homeostasis requires tight control of adult stem cells and differentiation throu...
In the past decade, enormous progress has been made in understanding the role of stem cells in physi...
Throughout the lifetime of an organism, progenitor cells in the intestine proliferate and differenti...
The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem and ...
The gastric epithelium is sustained by a population of stem cells that replenish the various mature ...
Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and pr...
: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focu...
Copyright © The Histochemical SocietyThe Notch signaling pathway has become recognized as a vitally ...