Despite 20 years since its discovery, the gene responsible for Huntington’s Disease, HTT, has still not had its function or transcriptional profile completely characterized. In response to a recent report by Ruzo et al. of several novel splice forms of HTT in human embryonic stem cell lines, we have analyzed a set of mRNA sequencing datasets from post mortem human brain from Huntington’s disease, Parkinson’s disease, and neurologically normal control subjects to evaluate support for previously observed and to identify novel splice pat-terns. A custom analysis pipeline produced supporting evidence for some of the results reported by two previous studies of alternative isoforms as well as identifying previously unreported splice patterns. All...
Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded ...
Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that mani...
Neuropsin (kallikrein 8, KLK8) is a secreted-type serine protease preferentially expressed in the ce...
<div><p>Despite 20 years since its discovery, the gene responsible for Huntington’s Disease, <i>HTT<...
Despite 20 years since its discovery, the gene responsible for Huntington's Disease, HTT, has still ...
Background HD pathogenic mechanisms are complex with studies largely centred on the mutant HTT prote...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG expans...
Background: In Huntington's disease (HD), a CAG repeat expansion mutation in the Huntingtin (HTT) ge...
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by a patholo...
Background: A CAG repeat expansion in HTT has been known to cause Huntington’s disease for over 20 y...
Alternative splicing (AS) appears to be altered in Huntington’s disease (HD), but its significance f...
<p>A) Read pileup of the superset reads showing coverage in exons and specific introns. Canonical HT...
Data de publicació electrònica: 16-03-2021Correction of mis-splicing events is a growing therapeutic...
Post-transcriptional regulation is a set of important biological functions taking place during the g...
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the fi...
Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded ...
Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that mani...
Neuropsin (kallikrein 8, KLK8) is a secreted-type serine protease preferentially expressed in the ce...
<div><p>Despite 20 years since its discovery, the gene responsible for Huntington’s Disease, <i>HTT<...
Despite 20 years since its discovery, the gene responsible for Huntington's Disease, HTT, has still ...
Background HD pathogenic mechanisms are complex with studies largely centred on the mutant HTT prote...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG expans...
Background: In Huntington's disease (HD), a CAG repeat expansion mutation in the Huntingtin (HTT) ge...
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by a patholo...
Background: A CAG repeat expansion in HTT has been known to cause Huntington’s disease for over 20 y...
Alternative splicing (AS) appears to be altered in Huntington’s disease (HD), but its significance f...
<p>A) Read pileup of the superset reads showing coverage in exons and specific introns. Canonical HT...
Data de publicació electrònica: 16-03-2021Correction of mis-splicing events is a growing therapeutic...
Post-transcriptional regulation is a set of important biological functions taking place during the g...
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the fi...
Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded ...
Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that mani...
Neuropsin (kallikrein 8, KLK8) is a secreted-type serine protease preferentially expressed in the ce...