Add to ORKGOver the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that...
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify c...
are candidates for breast and ovarian cancer susceptibility. and the risks of breast cancer and inv...
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has bec...
Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of ...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition...
Ovarian cancer is a highly lethal disease. Many researchers have, therefore, attempted to identify h...
BACKGROUND:Recent studies have identified several single nucleotide polymorphisms (SNPs) in the popu...
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify c...
Advances in next-generation sequencing and the decreasing cost of technology have widened access to ...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a major heritable component. The dif...
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explai...
It is estimated that 5-10% of breast cancers (BC) and 25% of ovarian cancers (OC) are caused by inhe...
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explai...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that...
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify c...
are candidates for breast and ovarian cancer susceptibility. and the risks of breast cancer and inv...
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has bec...
Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of ...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition...
Ovarian cancer is a highly lethal disease. Many researchers have, therefore, attempted to identify h...
BACKGROUND:Recent studies have identified several single nucleotide polymorphisms (SNPs) in the popu...
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify c...
Advances in next-generation sequencing and the decreasing cost of technology have widened access to ...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a major heritable component. The dif...
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explai...
It is estimated that 5-10% of breast cancers (BC) and 25% of ovarian cancers (OC) are caused by inhe...
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explai...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that...
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify c...