COMMENTARY www.landesbioscience.com Worm e22497-1 Worm 2:2, e22497; April/May/June 2013; © 2013 Landes Bioscience COMMENTARY

edu The presence of too many or too few centrosomes at mitosis can disrupt the timely formation of a bipolar spindle and may lead to aneuploidy and cancer. Strict control of centrosome duplication is therefore crucial. Centrosome duplica-tion must occur once per cell cycle and the number of new centrioles made must be tightly controlled. The importance of protein degradation for the orderly pro-gression of the cell cycle has long been recognized, but until recently the role of proteolysis in the regulation of centro-some duplication had not been appre-ciated. Recent evidence suggests that restricting protein levels so that a single new centriole is built next to each pre-existing centriole is one way in which centrosome duplication is controlled. Here we discuss our recent finding that the SCF ubiquitin ligase complex regu-lates centrosome duplication in C. elegans in the larger context of the proteolytic regulation of centrosome duplication