Associations among Pericolonic Fat, Visceral Fat, and

OBJECTIVE—To determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC). METHODS—1169 patients who underwent CTC and same day optical colonoscopy were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue volume was measured at the L2-L3 levels. Student t-tests, odds ratio, logistic regression, binomial statistics and weighted-kappa were performed to ascertain associations with the incidence of colorectal polyps. RESULTS—Pericolonic fat volume fractions (PFVF) were 61.5±11.0 % versus 58.1±11.5%, 61.6 ±11.1 % versus 58.7±11.5%, and 62.4±10.6 % versus 58.8±11.5 % for patients with and without any polyps, adenomatous polyps, and hyperplastic polyps, respectively (p<0.0001). Similar trends were observed when examining visceral fat volume fractions (VFVF). When patients were ordered by quintiles of PFVF or VFVF, there were 2.49, 2.19 and 2.39-fold increases in odds ratio for the presence of any polyp, adenomatous polyps, or hyperplastic polyps from the first to the fifth quintile for PFVF, and 1.92, 2.00 and 1.71-fold increases in odds ratio for VFVF. Polyps tended t