RESEARCH ARTICLE The Impact of Smoking on Airflow Limitation in Subjects with History of Asthma and Inactive Tuberculosis

Background Although smoking is the most important and modifiable cause of chronic obstructive pulmo-nary disease (COPD), other risk factors including asthma and tuberculosis (TB) are also as-sociated. It is common for COPD patients to have more than one of these risk factors. The aims of this study were to determine the prevalence of airflow limitation (FEV1/FVC<0.7) ac-cording to the risk factors and to investigate their impact and interaction in airflow limitation. Methods From the Korean National Health and Nutrition Examination Survey between 2008 and 2012, we analyzed participants over 40 years of age by spirometry, chest radiograph and questionnaire about asthma and smoking history. Results Of 12,631 participants, 1,548 (12.3%) had airflow limitation. The prevalence of airflow limita-tion in smokers (10 pack-year), asthmatics, and those with inactive TB was 23.9%, 32.1%, and 33.6%. The prevalence increased with the number of risk factors: 86.1 % had airflow limi