Original Article Evaluation of Some Plasma Coagulation Factors in Women with Spontaneous Miscarriage

Background: It has been reported that 15-20 % of parous female have experienced at least one miscarriage, while 3 % of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a his-tory of spontaneous abortions. Materials and Methods: In this case-control study, 82 women with a history of two or more abortions referred to the six private gynecologic clinics in Gorgan city without any structural abnormality were recruited during 2011-2012. Plasma levels of antithrom-bin III (ATIII) using colorimetric assay, protein C, protein S, factor V Leiden and lupus anticoagulant (LAC) using coagulation method were measured. The control group was women with a history of normal delivery and no abortions. Those under anti-coagulant therapy were excluded from the study. Data were entered into the computer using the Statistical Package for the Social Sciences (SPSS, SPSS Inc., Chicago, IL, USA) version 16 and analyzed by Chi-square, t test and non-parametric tests. Results: At least one abnormality was reported in 35 cases (42.7%). Among them, pro