Decreasing Mortality in Severe Sepsis and Septic Shock Patients by Implementing a Sepsis Bundle in a Hospital Setting

Ra Christina Pereira Lima Shiramizo
Re R. Marra
Marcelino S. Durão
Ângela T. Paes
Michael B. Edmond
Oscar Fern
O Pavão Dos Santos

Publication date

January 2011

Abstract

Background: The Surviving Sepsis Campaign (SSC) guidelines for the management of severe sepsis (SS) and septic shock (SSh) have been recommended to reduce morbidity and mortality. Materials and Methods: A quasi-experimental study was conducted in a medical-surgical ICU. Multiple interventions to optimize SS and SSh shock patients ’ clinical outcomes were performed by applying sepsis bundles (6- and 24-hour) in May 2006. We compared bundle compliance and patient outcomes before (July 2005-April 2006) and after (May 2006-December 2009) implementation of the interventions. Results: A total of 564 SS and SSh patients were identified. Prior to the intervention, compliance with the 6 hour-sepsi